Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyCiliary Function and Immunity Lab
Lisa Miorin · New York, New York
Research Focus
Dr. Lisa Miorin's lab focuses on understanding how specific genetic mutations affect the body's ability to fight off infections, particularly influenza. By studying a protein called ANKEF1 that helps move cilia in airway cells, the lab investigates how mutations can lead to severe complications like pneumonia and encephalitis. The research utilizes advanced technologies to explore the relationships between ciliary function, viral infections, and immune responses to identify potential new therapies for severe respiratory diseases.
influenzaciliary functionhost defenseANKEF1viral infectionmucociliary clearanceinnate immunity
Research Aims
3AIM 01Investigate how ANKEF1 deficiency affects ciliary beat frequency in airway and brain cells.
AIM 02Characterize disease progression in ANKEF1-deficient mice and assess viral load and immune responses.
AIM 03Elucidate the molecular mechanisms by which ANKEF1 regulates ciliary functions and immune responses.
Skills the Lab Values
mouse modelshuman iPSC-derived culturessingle-cell RNA sequencingspatial transcriptomicsimmunofluorescence microscopyviral titrationbiochemical assays
Output against the department
Publications96bottom 33% of dept.325th of 486
this lab
most publishedleast published
Citations17ktop 23% of dept.111th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.