Thomas Jefferson University · BiochemistryAndrogen-Linked Dynamics Lab
Diane E Merry · Philadelphia, Pennsylvania
Research Focus
Dr. Diane E Merry's lab focuses on understanding spinal and bulbar muscular atrophy (SBMA), a neurodegenerative disease caused by mutations in the androgen receptor. By studying cellular and animal models, the lab aims to uncover the role of protein interactions related to this disease and to develop potential therapeutic strategies. This work seeks to ultimately provide insights into not just SBMA, but also other neurodegenerative conditions associated with protein misfolding.
SBMAneurodegenerative diseasesprotein interactionsandrogen receptorpolyglutamine expansion
Research Aims
3AIM 01Investigate the interactome of the androgen receptor in SBMA models.
AIM 02Understand the mechanisms of toxicity related to polyglutamine expansion in SBMA.
AIM 03Develop therapeutic strategies targeting specific protein interactions in SBMA.
Skills the Lab Values
cell culture techniquesmouse modelsproteomicsco-immunoprecipitationbiochemical assays
Output against the department
Publications78bottom 16% of dept.339th of 402
this lab
most publishedleast published
Citations9.5kbottom 49% of dept.204th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.