University of Washington-Seattle Campus · Biomedical EngineeringVaccine Delivery Systems Lab
James D. Bryers · Seattle, Washington
Research Focus
Dr. James D. Bryers' lab focuses on innovative vaccine delivery systems using injectable hydrogels. They aim to develop self-replicating mRNA vaccines specifically targeting Staphylococcus aureus, a dangerous bacteria responsible for severe infections. By creating biodegradable hydrogel depots, the lab seeks to improve vaccine efficacy and safety through a single injection method rather than repeated doses.
mRNA vaccineStaphylococcus aureusbiodegradable hydrogelsvaccine deliveryself-replicating mRNA
Research Aims
4AIM 01Develop a biodegradable injectable hydrogel for vaccine delivery.
AIM 02Create nanoparticles that encapsulate self-replicating mRNA vaccines.
AIM 03Evaluate the immune response to the delivered mRNA vaccines.
AIM 04Test the effectiveness of the vaccine against Staphylococcus aureus infection.
Skills the Lab Values
injectable hydrogel preparationnanoparticle formulationpolymer chemistrymRNA handling and manipulationin vitro cell culture
Output against the department
Publications149bottom 32% of dept.401st of 595
this lab
most publishedleast published
Citations7.8ktop 45% of dept.265th of 595
this lab
most citedleast cited
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