Brigham Young University · Microbiology & ImmunologyTessem Beta Cell Lab
Jeffery Sivert Tessem · Provo, Utah
Research Focus
Dr. Jeffery Sivert Tessem's lab focuses on understanding how specific proteins can increase the mass of functional insulin-producing beta cells, which is crucial in treating diabetes. By studying the role of a protein called Nr4a1, the lab aims to discover new ways to enhance beta cell function and proliferation, potentially leading to better therapies for individuals with Type 1 and Type 2 diabetes. Their research could help address significant health challenges related to diabetes management.
beta cell massdiabetesGLP-1 receptorDyrk1aNr4a1insulin secretioncell proliferationpharmacological modulationtype 1 diabetestype 2 diabetes
Research Aims
3AIM 01Determine the effect of Nr4a1 in GLP-1R and Dyrk1a mediated functional beta-cell mass expansion.
AIM 02Investigate the role of Nr4a1 in the signaling pathways that lead to functional beta-cell mass expansion.
AIM 03Assess the impact of pharmacological modulation of Nr4a1 on beta-cell mass expansion.
Skills the Lab Values
cell culturemouse modelsgene expression analysisimmunohistochemistryWestern blottingRNA interferencepharmacological screeningbiochemical assaysprotein analysistranscription factor studies
Output against the department
Publications88bottom 29% of dept.344th of 486
this lab
most publishedleast published
Citations1.2kbottom 7% of dept.452nd of 486
this lab
most citedleast cited
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