Brown University · Microbiology & ImmunologyVitamin A and Gut Health Lab
Shipra Vaishnava · Providence, Rhode Island
Research Focus
Dr. Shipra Vaishnava's lab at Brown University studies how vitamin A interacts with gut bacteria to influence immune health and gut barrier function. They explore the role of retinoic acid, a vitamin A metabolite, in regulating immune responses and epithelial regeneration, aiming to reveal new insights that could lead to dietary or microbial therapies for diseases involving gut barrier dysfunction.
vitamin Aretinoic acidgut microbiomeimmune responseepithelial regenerationintestinal healthintestinal epithelial cellsmucosal immunitybacterial metabolism
Research Aims
3AIM 01Determine how intestinal epithelial cells regulate T-cell responses through retinoic acid.
AIM 02Assess the role of vitamin A metabolism on stem cell behaviors in the gut.
AIM 03Investigate how different gut bacteria produce retinoic acid from dietary vitamin A.
Skills the Lab Values
mouse modelscell cultureflow cytometryPCRWestern blotRNA sequencingimmunohistochemistrymetabolic assaysbioinformatics
Output against the department
Publications59bottom 16% of dept.410th of 486
this lab
most publishedleast published
Citations4.8kbottom 36% of dept.311th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.