RUThe Rockefeller University · Microbiology & Immunology
Hatziioannou Lab
Theodora Hatziioannou · New York, New York
Research Focus
Dr. Theodora Hatziioannou's lab at Rockefeller University focuses on understanding how the body's antiviral defenses impact the ability of lentiviruses, like HIV-1, to infect hosts. By studying how specific proteins in the immune system respond to these viruses, her team aims to identify ways that lentiviruses evade detection and resistance. This research is critical for developing better strategies for preventing and treating HIV-related diseases.
HIV-1primate lentivirusesinterferonantiviral proteinschimeric virusesimmune responseviral entryCRISPR
Research Aims
5AIM 01Explore the mechanism of action of antiviral ISGs affecting viral entry.
AIM 02Determine the molecular details of how interferons inhibit HIV-1 entry.
AIM 03Evaluate the effects of type I interferon on primate lentivirus replication in macaques.
AIM 04Assess the impact of novel ISGs on HIV-1 sensitivity in different strains.
AIM 05Investigate how type I interferon affects SHIV dissemination in vivo.
Skills the Lab Values
CRISPR screeningcell cultureanimal modelsviral assaysimaging techniquesmolecular cloningbarcodingin vivo experimentsviral protein analysis
Output against the department
Publications161top 42% of dept.203rd of 486
this lab
most publishedleast published
Citations24ktop 15% of dept.71st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.