University of Alabama at Birmingham · NeuroscienceCognitive Resilience Research Lab
Jeremy H. Herskowitz · Birmingham, Alabama
Research Focus
Dr. Jeremy H. Herskowitz runs a research lab focused on understanding how some individuals can maintain cognitive function despite having Alzheimer's disease pathology in their brains. The lab aims to identify the molecular and cellular mechanisms that contribute to this resilience and discover potential therapeutic targets for delaying or preventing dementia. By studying brain regions and synaptic health, they hope to pave the way for new treatments that improve cognitive function in older adults at risk for Alzheimer's disease.
Alzheimer's diseasesynaptic resiliencecognitive functiondrug targetingmolecular mechanisms
Research Aims
3AIM 01Identify synaptic signaling pathways that support cognitive abilities in resilient individuals.
AIM 02Investigate how amyloid-beta and tau interact with dendritic spines to influence brain connectivity.
AIM 03Identify protein targets for therapeutic development to support cognitive functions across brain regions.
Skills the Lab Values
CRISPRanimal modelscell culturefunctional magnetic resonance imaging (fMRI)electrophysiologyproteomicsdata analysiscomputer modeling
Output against the department
Publications61bottom 15% of dept.571st of 671
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.593rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.