University of California-Davis · BiologyEnvironmental Neurotoxicity Research Group
Pamela J Lein · Davis, California
Research Focus
Dr. Pamela J. Lein's lab at UC Davis focuses on understanding how environmental toxins, specifically polychlorinated biphenyls (PCBs) and traffic-related air pollution, affect brain development and contribute to diseases like Alzheimer's. By using advanced animal models, the lab investigates the mechanisms by which these pollutants disrupt normal neurological processes, aiming to inform public health strategies for minimizing risks associated with environmental exposures.
PCBsneurodevelopmentAlzheimer's diseasetraffic-related air pollutionneurotoxicity
Research Aims
4AIM 01Investigate the developmental neurotoxicity of lower-chlorinated PCBs in animal models.
AIM 02Examine how cytochrome P450 metabolism influences PCB effects on brain development.
AIM 03Analyze the impact of traffic-related air pollution on Alzheimer's disease phenotypes in experimental rats.
AIM 04Determine the role of lung inflammation in neurodegeneration caused by air pollution exposure.
Skills the Lab Values
cell cultureanimal modelsneuroinflammatory assaysPCRWestern blottingRNA sequencinghistological analysisbehavioral testingquantitative analysis
Output against the department
Publications405top 12% of dept.119th of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.279th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.