University of Rhode Island · BiochemistryRothman Lab
Alan L Rothman · Kingston, Rhode Island
Research Focus
Dr. Alan L. Rothman's lab at the University of Rhode Island focuses on understanding how vaccinations against the dengue virus create lasting immunity. By studying immune responses over time in individuals who received the dengue vaccine, the lab aims to find out what makes some immune responses strong and enduring while others fade. This research could help improve future vaccine designs.
dengue virusvaccinationimmune responseantibody durabilityT and B lymphocytesepigeneticstranscriptomicsvaccine developmentflow cytometryRNA sequencing
Research Aims
3AIM 01Identify T and B cell functional responses associated with long-term antibody persistence after vaccination.
AIM 02Determine gene expression and epigenetic profiles in T and B lymphocytes that predict durable immunity.
AIM 03Validate the immunological signatures of long-lasting antibody responses to dengue vaccine recipients.
Skills the Lab Values
flow cytometrysingle-cell RNA sequencingimmunological assaysgene expression analysisepigenetic profilingcell sortinglongitudinal studiesdata interpretationvaccine trial analysisserological testing
Output against the department
Publications252top 29% of dept.117th of 402
this lab
most publishedleast published
Citations19ktop 22% of dept.89th of 402
this lab
most citedleast cited
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