University of Nebraska-Lincoln · BiochemistrySun Lab
Xinghui Sun · Lincoln, Nebraska
Research Focus
Dr. Xinghui Sun's lab at the University of Nebraska Lincoln focuses on understanding how specific proteins influence liver and endothelial cell health. One major area of research investigates how matrin-3 affects liver inflammation and fibrosis, which are key aspects of metabolic diseases like steatohepatitis. Another focus is on the role of neddylation in maintaining the integrity of endothelial cells, which are crucial for vascular health. This research aims to uncover molecular mechanisms that could lead to new therapeutic strategies for liver ailments and vascular diseases.
liver inflammationendothelial functionfibrosisneddylationmetabolic diseasesthrombinvascular integrityCAR signalinghepatocytesvascular diseases
Research Aims
5AIM 01Identify the molecular mechanisms by which matrin-3 regulates CAR signaling in liver disease.
AIM 02Determine the protective role of the matrin-3-CAR axis in hepatic inflammation and fibrosis.
AIM 03Investigate how neddylation maintains endothelial integrity and function.
AIM 04Explore the role of cullin-3 in endothelial cell survival and stress response.
AIM 05Uncover the relationships between neddylation, protein function, and vascular disease.
Skills the Lab Values
PCRRNA sequencingsingle-nucleus RNA-sequencingmouse modelsbiochemical assayscell culturetranscriptomic analysisproteomicsbioinformaticsflow cytometry
Output against the department
Publications77bottom 15% of dept.342nd of 402
this lab
most publishedleast published
Citations3.7kbottom 19% of dept.325th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.