WMCWeill Medical College of Cornell University · Physiology
Khurana Genomics Lab
Ekta Khurana · New York, New York
Research Focus
Dr. Ekta Khurana's lab at Weill Medical College focuses on understanding how specific regions of the genome that do not code for proteins can influence the initiation and growth of breast cancer. Using a combination of computational techniques and experimental approaches, the lab aims to identify and manipulate these non-coding genomic elements, particularly in the context of treatment resistance. This research is significant because it may lead to new strategies for cancer treatment by targeting non-coding regions that affect tumor growth.
breast cancernon-coding regionsgenome editingCRISPRtumor initiationtreatment resistanceliquid biopsyenhancer identificationbase editingcancer genetics
Research Aims
5AIM 01Identify non-coding enhancers critical for tumor growth in breast cancer.
AIM 02Develop computational methods to analyze genomic data from cancer patients.
AIM 03Investigate the role of enhancer perturbation in therapy resistance.
AIM 04Use CRISPR technology to assess the effects of mutations in non-coding regions.
AIM 05Explore interactions between non-coding drivers and breast cancer therapies like aromatase inhibitors.
Skills the Lab Values
CRISPRwhole-genome sequencingcell-free DNA analysisbase editinghigh-throughput screeningcell culturesingle-cell sequencingbioinformaticsgene expression analysisplasma sample processing
Output against the department
Publications172top 41% of dept.118th of 286
this lab
most publishedleast published
Citations88ktop 1% of dept.1st of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.