Carnegie Mellon University · Biomedical EngineeringCohen-Karni Lab
Tzahi Cohen-Karni · Pittsburgh, Pennsylvania
Research Focus
Dr. Tzahi Cohen-Karni's lab at Carnegie-Mellon University focuses on understanding how DNA damage in heart cells can lead to heart disease. They explore the molecular mechanisms behind cardiac health by studying how damaged DNA affects cell communication and function in 3D heart tissue models. Their work aims to identify potential new treatments for heart failure and improve our understanding of how DNA damage impacts heart health.
DNA damagecardiomyocytescardiac healthcell signalingheart failure
Research Aims
3AIM 01Map the molecular and architectural changes in cardiomyocytes upon DNA damage.
AIM 02Investigate how DNA damage in cardiomyocytes affects neighboring cardiac fibroblasts.
AIM 03Analyze the secretome changes in response to genotoxic stress in heart tissues.
Skills the Lab Values
3D cardiac organoid cultureoptical measurement techniquesbioelectrical measurement techniqueselectrophysiologyCRISPR/Cas technology
Output against the department
Publications94bottom 15% of dept.506th of 595
this lab
most publishedleast published
Citations4.8kbottom 36% of dept.379th of 595
this lab
most citedleast cited
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