University of Arizona · PharmacologyEndocannabinoid Therapeutics Lab
Tally Marie Milnes · Tucson, Arizona
Research Focus
Dr. Tally Marie Milnes' research lab at the University of Arizona focuses on understanding how the endocannabinoid system can be targeted to treat conditions related to opioid use and headaches. The lab explores innovative approaches to investigating opioid-induced respiratory depression and migraine symptoms, combining techniques from pharmacology and molecular biology. Their work aims to develop new therapeutic strategies that could enhance current treatments for pain and opioid overdose management.
endocannabinoid systemopioid-induced respiratory depressionmigrainecannabinoid receptorspain managementdrug discovery
Research Aims
4AIM 01Identify the role of cannabinoid receptor 2 activation in mitigating opioid-induced respiratory depression.
AIM 02Investigate endocannabinoid levels in the brain during opioid-induced respiratory depression.
AIM 03Explore the mechanisms of endocannabinoid dysregulation in migraine headache pathology.
AIM 04Test the efficacy of selective inhibitors for enhancing endocannabinoid tone in headache treatment.
Skills the Lab Values
behavioral pharmacologywhole body plethysmographymolecular biologyanalytical chemistrygene-editing techniquesrodent modelsimmunohistochemistrydata analysis in laboratory settingsbiochemical assays
Output against the department
Publications131bottom 37% of dept.292nd of 462
this lab
most publishedleast published
Citations2.7kbottom 20% of dept.371st of 462
this lab
most citedleast cited
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