EUEmory University · Biochemistry
Ortlund Metabolism Lab
Eric A Ortlund · Atlanta, Georgia
Research Focus
Dr. Eric A. Ortlund's lab focuses on understanding and targeting a specific protein, LRH-1, which plays a key role in managing how our bodies process fats and sugars. By developing new small molecules that can activate LRH-1, the lab aims to find therapeutic solutions for diseases linked to obesity, like diabetes and fatty liver disease. They also create innovative mouse models to test these new treatments more effectively.
LRH-1metabolic diseasesobesitydiabetessmall moleculeslipid metabolismglucose homeostasisCRISPRtherapeutic development
Research Aims
3AIM 01Develop small molecules that effectively activate LRH-1.
AIM 02Characterize the mechanisms through which these small molecules enhance LRH-1 activity.
AIM 03Evaluate the pharmacokinetics and tractability of lead compounds using humanized mouse models.
Skills the Lab Values
CRISPR-Cas9 gene editingsmall molecule designmouse model generationbiophysical characterizationADME testingpharmacokineticsbiological assay developmenthigh-throughput screeningstructure-activity relationship analysis
Output against the department
Publications258top 28% of dept.113th of 402
this lab
most publishedleast published
Citations10ktop 48% of dept.193rd of 402
this lab
most citedleast cited
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