University of Chicago · GeneticsGolgi Apparatus Research Lab
Benjamin S Glick · Chicago, Illinois
Research Focus
Dr. Benjamin Glick's research lab at the University of Chicago focuses on understanding how the Golgi apparatus, a vital organelle in cells, regulates the traffic of proteins. By studying both yeast cells and mammalian cells, the lab investigates how proteins are organized, sorted, and recycled within the secretory pathway. Through advanced imaging techniques and genetic tools, they aim to unravel the molecular mechanisms that govern these processes, which are crucial for proper cell function.
Golgi apparatusprotein traffickingmembrane recyclingyeast biologymammalian cell culture4D fluorescence microscopyclathrin adaptorssecretory pathwaygenome editingcellular organization
Research Aims
5AIM 01Elucidate the molecular logic circuit controlling Golgi-associated membrane traffic pathways.
AIM 02Characterize the kinetics of proteins during cisternal maturation in yeast.
AIM 03Investigate recycling pathways for secretory proteins in both yeast and mammalian cells.
AIM 04Determine how different vesicle tethers and SNAREs coordinate membrane traffic timings.
AIM 05Explore the interactions of secretory cargoes and membrane organelles.
Skills the Lab Values
4D fluorescence microscopyyeast geneticsmammalian cell cultureprotein purificationlive cell imaginggenome editing (CRISPR)molecular cloningprotein taggingmicroscopy techniquesbiochemical assays
Output against the department
Publications234top 36% of dept.94th of 259
this lab
most publishedleast published
Citations17ktop 34% of dept.87th of 259
this lab
most citedleast cited
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