Columbia University in the City of New York · GeneticsCenter for DNA Repair Mechanisms
Rodney J. Rothstein · New York, New York
Research Focus
Dr. Rodney J. Rothstein's lab focuses on understanding how cells repair DNA damage, specifically double-strand breaks that can occur during DNA replication or due to external factors. Using yeast as a model organism, the lab investigates the complex processes involved in genetic recombination and how these mechanisms can lead to genome stability, which is crucial for preventing diseases like cancer. Through innovative experimental designs, the lab aims to shed light on the timing and roles of various proteins in the DNA repair process.
DNA repairgenetic recombinationdouble-strand breaksyeast modelcancerDNA damageCRISPRmolecular biologygenetics
Research Aims
5AIM 01Explore the mechanisms of DNA double-strand break repair in yeast cells.
AIM 02Investigate the repair process of various DNA break types using endonucleases.
AIM 03Visualize the process of successful genetic recombination.
AIM 04Study the role of specific proteins in template switch recombination.
AIM 05Understand the impact of genetic mutations on DNA repair timing.
Skills the Lab Values
cell biologymolecular biology techniquesyeast geneticsin vivo imagingCRISPR techniquesDNA sequencinggenetic manipulationprotein assayschromosome analysis
Output against the department
Publications196top 43% of dept.112th of 259
this lab
most publishedleast published
Citations28ktop 21% of dept.54th of 259
this lab
most citedleast cited
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