Washington University in St Louis · Microbiology & ImmunologyDoering Mycology Lab
Tamara L Doering · Saint Louis, Missouri
Research Focus
Dr. Tamara L. Doering's research focuses on understanding the complex cell wall of the fungus Cryptococcus neoformans, which causes serious infections in humans, particularly in individuals with compromised immune systems. The lab studies the biosynthesis of beta-16-glucan, a crucial component of the cell wall that is not adequately targeted by existing antifungal treatments. By investigating the role of specific proteins involved in cell wall assembly, the lab aims to uncover new therapeutic targets to combat cryptococcal infections.
Cryptococcus neoformanscell wall biosynthesisbeta-16-glucanantifungal therapyfungal pathogensglycosyltransferasepublic healthmicrobiologyimmunology
Research Aims
3AIM 01Define the cell wall structure of wild-type and ggt2 mutant Cryptococcus neoformans cells.
AIM 02Establish the biochemical function of the glycosyltransferase Ggt2 in cell wall synthesis.
AIM 03Identify proteins that participate in beta-16-glucan synthesis and study their mechanisms.
Skills the Lab Values
biochemical methodsbiophysical analysisgenetic strategiescell culture techniquesprotein characterizationmicroscopymolecular cloningRNA extractionWestern blotting
Output against the department
Publications149top 44% of dept.212th of 486
this lab
most publishedleast published
Citations8.5ktop 43% of dept.207th of 486
this lab
most citedleast cited
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