University of North Texas · BiologyPudur Lab
Pudur Jagadeeswaran · Denton, Texas
Research Focus
The research lab of Dr. Pudur Jagadeeswaran at the University Of North Texas focuses on understanding how genes influence the development of blood platelets from megakaryocytes, specifically using zebrafish as a model. By examining the genetic mechanisms involved in thrombopoiesis, the lab aims to uncover key factors that could help address conditions like thrombocytopenia, a disorder characterized by low platelet counts. The research not only advances basic biology but also has potential implications for improving treatments for blood-related diseases.
megakaryocytesthrombopoiesiszebrafishCRISPRsingle-cell RNA sequencingthrombocytopeniagene expressionblood plateletsdevelopmental biology
Research Aims
3AIM 01Generate CRISPR/Cas9-based knockouts for newly identified genes in thrombocytes.
AIM 02Perform single-cell RNA sequencing on young and mature thrombocytes to identify differentially expressed genes.
AIM 03Conduct knockdowns of downstream genes using high-throughput methods to understand thrombocyte development.
Skills the Lab Values
CRISPR/Cas9 gene editingsingle-cell RNA sequencingzebrafish husbandryflow cytometrymolecular cloninggene expression analysishigh-throughput screeningdata analysis in Rcell culture
Output against the department
Publications133bottom 47% of dept.543rd of 1,033
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.649th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.