University of North Carolina at Chapel Hill · PharmacologyDohlman Signaling Lab
Henrik G. Dohlman · Chapel Hill, North Carolina
Research Focus
Dr. Henrik G. Dohlman's lab at the University of North Carolina Chapel Hill focuses on the intricacies of cell signaling mediated by G protein-coupled receptors. The lab's research aims to uncover the unique behaviors of different G protein subtypes and how they interact with hormones, neurotransmitters, and drugs. Their work is significant for understanding human diseases and could lead to the development of better pharmaceutical treatments.
G protein-coupled receptorscell signalingpharmacologyGTP-binding proteinsdrug discovery
Research Aims
5AIM 01Characterize the differences among G protein subtypes during activation and inactivation.
AIM 02Identify the structural and functional repertoire of G proteins in their nucleotide-free state.
AIM 03Establish the impact of receptor ligands on G protein activation and signaling.
AIM 04Investigate the effects of rare disease variants on G protein function.
AIM 05Revolutionize drug discovery processes by establishing a mechanistic basis for G protein signaling.
Skills the Lab Values
biophysical analysisbiochemical analysiscell culturepharmacology techniquesprotein dynamicsligand binding assays
Output against the department
Publications219top 38% of dept.177th of 462
this lab
most publishedleast published
Citations13ktop 30% of dept.137th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.