Baylor College of Medicine · BiochemistryRNA Splicing and Immunotherapy Lab
Thomas Westbrook · Houston, Texas
Research Focus
Dr. Thomas Westbrook's lab at Baylor College of Medicine focuses on developing innovative strategies to treat triple-negative breast cancer (TNBC), a particularly aggressive form of cancer. The lab studies how manipulating RNA splicing can activate the immune response against tumors, potentially improving the efficacy of cancer therapies. By understanding the relationship between RNA splicing and immune signaling, the lab aims to enhance treatment outcomes for TNBC patients.
RNA splicingtriple-negative breast cancerimmunotherapyspliceosome-targeted therapyimmune response
Research Aims
3AIM 01Investigate combinatorial therapy approaches based on spliceosome-targeted therapy-induced antitumor immune response.
AIM 02Define cellular modulators of endogenous double-stranded RNA-mediated antiviral signaling.
AIM 03Evaluate features of spliceosome-targeted therapy-induced mis-spliced RNA that stimulate antiviral signaling.
Skills the Lab Values
RNA sequencingcell cultureimmunofluorescencegenetic screeningmouse modelschemical geneticsdata analysisbioinformaticsWestern blot
Output against the department
Publications162bottom 46% of dept.217th of 402
this lab
most publishedleast published
Citations15ktop 33% of dept.131st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.