MUSMedical University of South Carolina · Biology
The Myosin Lab
Amy C Engevik · Charleston, South Carolina
Research Focus
Dr. Amy C Engevik's lab focuses on understanding how specific proteins in our intestines influence gut health, particularly in the context of inflammatory bowel disease (IBD). The team studies a protein called Myosin 5b, which helps transport key enzymes that protect our intestines from inflammation. By exploring the relationship between Myosin 5b and intestinal alkaline phosphatase, they aim to uncover new insights that could lead to better treatments for IBD.
inflammatory bowel diseaseintestinal healthinflammationMyosin 5balkaline phosphataseintestinal epithelial cellsmicrovillianimal models
Research Aims
5AIM 01Investigate the role of Myosin 5b in intestinal inflammation.
AIM 02Analyze how Myosin 5b affects the trafficking of alkaline phosphatase in epithelial cells.
AIM 03Examine the relationship between microvilli function and gut inflammation.
AIM 04Use in vitro and in vivo models to study the pathogenesis of IBD.
AIM 05Assess the impact of Myosin 5b loss on intestinal health.
Skills the Lab Values
cell cultureanimal modelsadvanced microscopymolecular biology techniquesCRISPR/Cas technologyprotein assayshistologygene expression analysis
Output against the department
Publications128bottom 46% of dept.557th of 1,033
this lab
most publishedleast published
Citations2.8kbottom 20% of dept.823rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.