Washington University in St Louis · BiochemistryDNA Repair and Maintenance Lab
Timothy M Lohman · Saint Louis, Missouri
Research Focus
Dr. Timothy Lohman's research lab focuses on understanding how specific proteins help maintain the genetic material in cells. Their work centers around DNA helicases and single-stranded DNA binding proteins, which are crucial for processes like DNA replication and repair. By studying the mechanisms of these proteins, the lab aims to uncover insights that could lead to the development of new treatments for diseases caused by mutations in these proteins.
DNA helicasesSSB proteinsDNA repairgenome maintenancetranslocasesE. coliM. tuberculosisCryo-EMprotein interactionsnucleic acid metabolism
Research Aims
5AIM 01Investigate the mechanisms of DNA unwinding by helicases.
AIM 02Examine the role of single-stranded DNA binding proteins in binding to DNA.
AIM 03Determine how mutations in helicases affect their function.
AIM 04Understand the dimerization process of helicases and its regulation.
AIM 05Explore the cooperative binding of SSB proteins to single-stranded DNA.
Skills the Lab Values
Cryo-electron microscopyDNA binding assaysprotein purificationkinetics analysismolecular cloningthermodynamic studiessingle molecule techniquesbiophysical characterizationcell-free protein expressionsite-directed mutagenesis
Output against the department
Publications272top 25% of dept.100th of 402
this lab
most publishedleast published
Citations22ktop 19% of dept.75th of 402
this lab
most citedleast cited
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