University of Texas Southwestern Medical Center · NeuroscienceStroud Lab
Hume Akahori Stroud · Dallas, Texas
Research Focus
Dr. Hume Akahori Stroud's research lab focuses on understanding the molecular mechanisms behind neurodevelopmental disorders like Rett Syndrome and autism. The lab studies the roles of important proteins, such as MECP2 and DNMT3A, in gene regulation within the brain. By exploring how these proteins interact with DNA and affect gene expression, the lab aims to uncover new strategies for treating these neurological conditions.
Rett SyndromeDNMT3Agene regulationneurodevelopmental disordersmethylation
Research Aims
5AIM 01Define the interaction between MECP2 and MECP2-Binding Hotspots (MBHs).
AIM 02Elucidate the molecular mechanisms by which MBHs repress enhancers.
AIM 03Examine the role of DNMT3A phosphorylation in gene regulation.
AIM 04Define the role of methylated CA sequences in neural gene regulation.
AIM 05Investigate how neuronal activity influences DNMT3A function.
Skills the Lab Values
molecular cloningcell cultureCRISPRgene expression profilingprotein purification