EUEmory University · Genetics
Conneely Hematology Lab
Karen Conneely · Atlanta, Georgia
Research Focus
Dr. Karen Conneely's lab at Emory University focuses on understanding how genetic mutations in blood stem cells can influence the risk of cardiovascular diseases, particularly in older adults. They use advanced genomic technologies to analyze samples from large populations, looking at how DNA modifications and gene expression patterns change in individuals with clonal hematopoiesis. This research aims to uncover the biological pathways that connect these genetic changes to heart health.
clonal hematopoiesiscardiovascular diseaseepigeneticsgene expressionRNA splicing
Research Aims
4AIM 01Investigate the differences in DNA methylation and gene expression between individuals with and without clonal hematopoiesis.
AIM 02Identify immune cell types driving CHIP-related transcriptomic and methylomic changes.
AIM 03Use Mendelian randomization to find causal relationships between CHIP mutations and cardiovascular disease risk.
AIM 04Integrate multi-omics data to understand how genetic mutations affect cardiovascular disease risk.
Skills the Lab Values
PCRRNA sequencingDNA methylation analysisbioinformaticsdeep learning modelingdata analysismulti-omics integrationstatistical geneticsclinical cohort studies
Output against the department
Publications299top 28% of dept.72nd of 259
this lab
most publishedleast published
Citations18ktop 32% of dept.84th of 259
this lab
most citedleast cited
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