University of Connecticut · NeuroscienceVerma RNA Lab
Rajkumar Verma · Storrs, Connecticut
Research Focus
Dr. Rajkumar Verma's lab at the University of Connecticut focuses on developing new treatments for ischemic stroke using innovative RNA inhibitors. The lab studies microRNAs, specifically the miR-141-3p family, which are found to be significantly upregulated in stroke patients. By creating advanced peptide nucleic acid (PNA) analogs that inhibit this microRNA, the research aims to reduce stroke injury and improve long-term recovery outcomes in animal models. Their work emphasizes the potential of miRNA-targeted therapy as a novel approach to address stroke-related disabilities.
RNA inhibitorsischemic strokemicroRNAspeptide nucleic acidsstroke therapy
Research Aims
3AIM 01Synthesize and characterize new PNA-based miR-141-3p inhibitors
AIM 02Identify the most effective PNA inhibitors and study their effects on stroke
AIM 03Determine optimal treatment windows and assess long-term recovery in aged mice after stroke
Skills the Lab Values
PNA synthesismicroRNA analysisanimal models of strokehigh-throughput screeningcharacterization of nucleic acids
Output against the department
Publications95bottom 31% of dept.462nd of 671
this lab
most publishedleast published
Citations2.5kbottom 16% of dept.563rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.