Baylor College of Medicine · GeneticsCenter for Genomic and Skeletal Research
Brendan Lee · Houston, Texas
Research Focus
Brendan Lee's lab at Baylor College of Medicine focuses on understanding the genetic and cellular basis of disease to improve diagnostics and treatment options, particularly for newborns and patients with complex skeletal conditions. The lab is leading innovative projects that use advanced technologies like genomic sequencing and neuroanatomical mapping to enhance medical care in underserved areas. Through their research, they aim to reduce health disparities and develop new therapeutic strategies for various conditions, including osteoarthritis and Osteogenesis Imperfecta.
genomic medicineskeletal stem cellsneuroanatomyosteogenesis imperfectagene therapyhealth disparitiestelehealthdata integrationneonatal care
Research Aims
5AIM 01Map neuronal connectivity in the knee joint to understand pain mechanisms.
AIM 02Improve genomic medicine access for sick newborns in Texas using telehealth.
AIM 03Investigate the role of skeletal stem cells in bone repair and homeostasis.
AIM 04Assess the impact of WNT signaling on craniofacial stem cells.
AIM 05Continue development of a clinical site for undiagnosed diseases.
Skills the Lab Values
genome sequencingtissue clearing techniquesviral vector designsingle cell RNA sequencingflow cytometrymolecular profilingdata analysisCRISPRcell cultureanimal models
Output against the department
Publications518top 13% of dept.33rd of 259
this lab
most publishedleast published
Citations23ktop 24% of dept.63rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.