University of Rochester · PharmacologySalivary Gland Research Lab
David I Yule · Rochester, New York
Research Focus
Dr. David Yule's research lab focuses on understanding the mechanisms behind saliva secretion in order to address conditions like dry mouth, which can severely affect quality of life. The lab employs a combination of experimental techniques and computer modeling to explore how salivary glands function normally and how these processes are disrupted in diseases such as Sjogren's syndrome. By investigating the cellular activities involved in saliva production, the lab hopes to develop new therapies for patients suffering from reduced saliva flow.
saliva secretionsjogren's syndromecalcium signalingcomputational modelingcellular mechanismstherapeutic interventionsdry mouthsalivary glandsion channelsacinar cells
Research Aims
5AIM 01Investigate the cellular mechanisms that regulate saliva secretion.
AIM 02Develop a computational model to predict salivary gland function under normal and pathological conditions.
AIM 03Identify cellular pathways disrupted in Sjogren's syndrome using RNA sequencing.
AIM 04Validate the model findings through experimental approaches in human tissues.
AIM 05Suggest novel therapeutic targets based on the understanding of secretion mechanisms.
Skills the Lab Values
cell culturesingle cell RNA sequencingin vivo imagingcomputational modelingCa2+ signaling analysismicrodissection techniquesprotein assaysdata analysismouse modelssurgical techniques
Output against the department
Publications292top 27% of dept.123rd of 462
this lab
most publishedleast published
Citations11ktop 36% of dept.165th of 462
this lab
most citedleast cited
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