UMCUniversity of Massachusetts Chan Medical School · Biology
Benanti Lab
Jennifer A Benanti · Worcester, Massachusetts
Research Focus
Dr. Jennifer A Benanti's lab studies how cells grow and divide, focusing specifically on the cell cycle, which is crucial for normal development and cancer prevention. By investigating molecular mechanisms, particularly the role of phosphorylation, her research aims to uncover how cells respond to stress and how mutations can contribute to diseases like cancer. Overall, her work seeks to find new strategies for controlling cellular proliferation and improving therapeutic approaches in oncology.
Cell CyclePhosphorylationCancerCell DivisionStress ResponseCyclin-Dependent KinasesCell GrowthTranscription FactorsMolecular Mechanisms
Research Aims
5AIM 01Understand how multisite phosphorylation regulates protein function in cell cycle progression.
AIM 02Investigate the adaptation of cells to chronic stress and its impact on the cell cycle.
AIM 03Explore how cell cycle regulation can contribute to resistance against therapies in cancer cells.
AIM 04Identify molecular targets for potential intervention to inhibit cancer cell proliferation.
AIM 05Examine conservation of cell cycle mechanisms from yeast to human cells.
Skills the Lab Values
Molecular Biology TechniquesCell CultureYeast ModelsHigh-Throughput ScreeningPhosphorylation AnalysisExperimental DesignStress Adaptation StudiesData InterpretationProtein Function Assays
Output against the department
Publications40bottom 8% of dept.953rd of 1,033
this lab
most publishedleast published
Citations1.0kbottom 5% of dept.983rd of 1,033
this lab
most citedleast cited
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