Duke University · BiochemistryMeyer Epitranscriptomics Lab
Kathryn D Meyer · Durham, North Carolina
Research Focus
Dr. Kathryn D Meyer's lab focuses on understanding how certain modifications to RNA affect the functioning of immune cells in the brain, particularly in the context of Alzheimer's disease. The research aims to unravel how microglia, the brain's immune cells, respond to inflammation and contribute to neurodegeneration. By studying a specific RNA modification known as m6A, the lab seeks to uncover new potential biomarkers and treatment targets for Alzheimer's disease.
Alzheimer's diseasemicrogliam6A modificationneuroinflammationneurodegenerationgene expressiontherapeutic targetsRNA-Protein interactionbiomarker discoveryepitranscriptomics
Research Aims
5AIM 01Investigate how m6A modifications influence microglial activation in response to inflammation
AIM 02Identify the dynamic m6A sites in microglia during Alzheimer's disease progression
AIM 03Explore the proteins that interact with m6A in microglial cells and their impact on gene expression
AIM 04Understand the role of m6A in determining microglial function and its implications for Alzheimer's disease
AIM 05Develop novel mouse models to assess the effects of microglial-specific depletion of m6A on disease progression.
Skills the Lab Values
mRNA methylation analysismolecular cloningmouse modelsRNA sequencingflow cytometrycell cultureWestern blotimmunohistochemistryin vivo imagingbioinformatics