University of Chicago · ChemistryMoellering Cancer Lab
Raymond E Moellering · Chicago, Illinois
Research Focus
The lab of Dr. Raymond E. Moellering at the University of Chicago focuses on developing innovative strategies to combat triple-negative breast cancer (TNBC) by targeting specific transcription factors that drive tumor growth. Using engineered synthetic transcriptional repressors (STRs), the lab aims to inhibit the activity of key proteins that enable cancer cells to survive in stressful environments. This research not only seeks to advance our understanding of cancer biology but also to create novel therapeutic options that could improve patient outcomes.
transcription factorssynthetic biologytriple-negative breast cancerdrug developmentcancer metabolism
Research Aims
3AIM 01Develop ultra-potent pharmacologically stable STRs for in vitro and in vivo studies.
AIM 02Map the effect of STRs on gene expression related to hypoxia in TNBC.
AIM 03Evaluate the therapeutic efficacy of STRs in inhibiting TNBC growth and metastasis.
Skills the Lab Values
cell cultureanimal modelsbiochemical assaysChIP-seqRNA sequencinggene expression analysisprotein-DNA interaction studiestranscriptional repression techniquesdrug delivery methodsdata analysis in biology
Output against the department
Publications63bottom 11% of dept.192nd of 216
this lab
most publishedleast published
Citations2.9kbottom 19% of dept.174th of 216
this lab
most citedleast cited
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