University of Chicago · BiologyEsterhazy Immunology Lab
Daria Esterhazy · Chicago, Illinois
Research Focus
Dr. Daria Esterhazy's lab focuses on understanding how certain immune cells, known as innate lymphocytes, develop and function in the body. These cells play a crucial role in our immune responses, particularly in how we react to infections and other challenges. The research involves exploring the genetic regulation of these cells to better understand their roles in health and disease, which could lead to new treatments for autoimmune diseases and infections.
innate lymphocytestranscription factorsimmune responseCRISPRepigeneticsnatural killer cellsautoimmunityallergic inflammationmouse models
Research Aims
3AIM 01Identify candidate enhancers that regulate the NK cell developmental pathway.
AIM 02Validate the functional role of these enhancers using CRISPR technology.
AIM 03Generate enhancer-reporter mouse strains to manipulate NK cell populations.
Skills the Lab Values
ATAC-seqCRISPR/Cas technologyflow cytometrybioinformaticsgenome-wide analysisenhancer reporter assaysmolecular cloningcell culturetissue isolationin vivo experimentation
Output against the department
Publications38bottom 6% of dept.964th of 1,033
this lab
most publishedleast published
Citations2.2kbottom 15% of dept.873rd of 1,033
this lab
most citedleast cited
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