University of Texas Southwestern Medical Center · PharmacologyCorey Lab
David R Corey · Dallas, Texas
Research Focus
Dr. David R. Corey’s lab focuses on understanding how nucleic acids interact with cells to regulate gene expression. The research aims to develop nucleic acid-based therapies for diseases, exploring mechanisms of RNA-mediated recognition, particularly in the cell nucleus. The lab's work has the potential to lead to innovative treatments for genetic disorders by manipulating gene expression at the molecular level.
nucleic acid therapeuticsgene regulationRNA interferencesmall binding RNAsdisease mechanismstargeted gene expressionFuchs Corneal Endothelial DystrophyPitt-Hopkins syndromegene silencingmolecular biology
Research Aims
5AIM 01Investigate how small binding RNAs recognize and regulate gene expression.
AIM 02Explore the mechanisms of nuclear RNA interference to control gene transcription.
AIM 03Develop targeted nucleic acid therapies for genetic disorders like Fuchs Corneal Endothelial Dystrophy.
AIM 04Identify endogenous miRNA targets for gene regulation in health and disease.
AIM 05Enhance understanding of gene regulatory mechanisms mediated by nucleic acids.
Skills the Lab Values
RNA extractionPCRcell cultureRNA sequencingnuclear RNAi analysissbRNA designin vivo delivery techniquesdrug discovery methodsmolecular cloninggene expression assays
Output against the department
Publications216top 39% of dept.182nd of 462
this lab
most publishedleast published
Citations15ktop 25% of dept.116th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.