Icahn School of Medicine at Mount Sinai · GeneticsLysine Metabolism Research Lab
Sander Michel Houten · New York, New York
Research Focus
Dr. Sander Houten's lab at the Icahn School of Medicine focuses on understanding and improving treatments for glutaric aciduria type 1 (GA1), a rare genetic disorder that affects the metabolism of lysine. The research team investigates the mechanisms that regulate lysine degradation in the body and explores new therapeutic strategies, including small molecule inhibitors that could lead to better treatment options for patients suffering from this condition. By studying the biochemistry of key enzymes involved in this process, the lab aims to address the unmet medical needs of GA1 patients, where current treatments often fall short.
lysine metabolismglutaric aciduria type 1enzyme regulationtherapeutic developmentmetabolic disorders
Research Aims
3AIM 01Investigate the allosteric regulation of lysine degradation enzymes.
AIM 02Develop small molecule inhibitors of succinyl-CoA:glutarate-CoA transferase.
AIM 03Validate therapeutic targets for glutaric aciduria type 1 in preclinical models.
Skills the Lab Values
X-ray crystallographybiochemical assayshigh-throughput screeningmedicinal chemistrycell culturemouse modelspharmacologyprotein purificationstructural biologydata analysis
Output against the department
Publications254top 32% of dept.83rd of 259
this lab
most publishedleast published
Citations19ktop 30% of dept.77th of 259
this lab
most citedleast cited
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