Rensselaer Polytechnic Institute · Biomedical EngineeringThe Fracture Insight Lab
Deepak Vashishth · Troy, New York
Research Focus
Deepak Vashishth's lab focuses on understanding how specific compounds in bone, particularly those formed during diabetes, affect fracture risk. They study advanced glycation end products (AGEs) like carboxymethyl-lysine (CML) to see how they alter bone quality and contribute to fragility fractures, especially in people with type 2 diabetes. The research could lead to better ways to predict and manage fractures in diabetic patients.
Type 2 DiabetesBone FracturesAdvanced Glycation EndproductsBone QualityCMLBiomarkersFracture RiskGlycationBone Mineral Density
Research Aims
3AIM 01Establish the conditions for enhanced formation of CML and its impact on bone toughness.
AIM 02Investigate how CML and AGEs alter the bone matrix in vertebrae and hip fractures.
AIM 03Validate CML as a biomarker of bone fragility associated with hyperglycemia.
Skills the Lab Values
Mouse ModelsBone HistologyBiochemical AssaysMicroCT ImagingTissue CultureBiomarker AnalysisStatistical AnalysisImmunohistochemistryDXA Scanning
Output against the department
Publications186bottom 43% of dept.337th of 595
this lab
most publishedleast published
Citations9.2ktop 37% of dept.222nd of 595
this lab
most citedleast cited
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