Washington University in St Louis · GeneticsEnhancer Regulation Lab
Barak A Cohen · Saint Louis, Missouri
Research Focus
Dr. Barak A Cohen's lab focuses on understanding how certain regions of our DNA, specifically enhancers, regulate gene expression, even when they are located far from the genes they influence. By examining these enhancers, the lab aims to uncover the features that enable them to function over long distances, which is important for understanding genetic variation and its role in diseases. This research combines innovative high-throughput techniques with genetic and genomic analysis to shed light on the complexities of gene regulation.
enhancersgene expressionnon-coding DNAgenetic variationhigh-throughputcis-regulatory elements
Research Aims
5AIM 01Identify the sequence features of enhancers that enable long-range gene regulation.
AIM 02Measure the activities of enhancers at various distances from target genes.
AIM 03Quantify the effects of transcription factor binding on enhancer function.
AIM 04Examine the chromatin environment's impact on enhancer activity.
AIM 05Develop a systematic framework for analyzing genetic variation related to enhancers.
Skills the Lab Values
high-throughput reportersDNA sequence analysischromatin analysistranscription factor binding studiesgenome editing techniquesdata quantification and modeling
Output against the department
Publications111bottom 34% of dept.170th of 259
this lab
most publishedleast published
Citations6.3kbottom 34% of dept.172nd of 259
this lab
most citedleast cited
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