University of Maryland, Baltimore · Microbiology & ImmunologyInnate Immune Defense Lab
Saumendra N Sarkar · Baltimore, Maryland
Research Focus
Dr. Saumendra N Sarkar's research lab at the University of Maryland Baltimore focuses on the innate immune response, specifically the role of interferon-stimulated genes (ISGs), namely Oligoadenylate Synthetase (OAS) proteins, in protecting against bacterial infections. The lab investigates how these proteins contribute to the immune defense against bacteria both in laboratory and in vivo settings, aiming to uncover mechanisms that could lead to new strategies for treating infectious diseases, particularly those involving antibiotic resistance.
innate immunityOAS proteinsbacterial infectionsantibiotic resistanceimmune response
Research Aims
3AIM 01Identify the mechanisms of cell-intrinsic antibacterial activity of OAS1.
AIM 02Determine the in vivo role of Oas1b in anti-bacterial innate immunity.
AIM 03Define the role of OASL in host defense against intracellular bacterial infections.
Skills the Lab Values
cell culturein vitro experimentsmolecular cloningmouse modelsbiochemical assays
Output against the department
Publications178top 37% of dept.182nd of 486
this lab
most publishedleast published
Citations6.2kbottom 45% of dept.265th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.