Icahn School of Medicine at Mount Sinai · NeuroscienceSlesinger Neuropharmacology Lab
Paul A Slesinger · New York, New York
Research Focus
Dr. Paul Slesinger's lab at the Icahn School of Medicine focuses on understanding how alcohol affects brain function and identifying new treatments for alcohol use disorders. The lab studies specific potassium channels that are involved in neuronal excitability, particularly in how mutations in these channels can lead to neurological diseases. By exploring the structure and function of these channels, the lab aims to develop new drugs that can effectively target and modulate their activity.
alcohol use disorderGIRK channelsion channelsneuropharmacologychannelopathies
Research Aims
5AIM 01Investigate how alcohol alters the function of GIRK channels in the brain.
AIM 02Identify new ligands for treating alcohol use disorders.
AIM 03Elucidate the mechanisms by which GIRK channel mutations lead to neurological diseases.
AIM 04Develop selective inhibitors for GIRK2 channels linked to Keppen-Lubinsky Syndrome.
AIM 05Create human neuron models to evaluate the therapeutic effects of GIRK channel inhibitors.
Skills the Lab Values
structural biologymolecular modelingneuroscience techniquescell culturehigh-resolution imaging (CryoEM)
Output against the department
Publications195top 38% of dept.253rd of 671
this lab
most publishedleast published
Citations9.8ktop 41% of dept.275th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.