University of California-Los Angeles · BiochemistryMikkola Lab
Hanna Katri Annikki Mikkola · Los Angeles, California
Research Focus
Dr. Hanna Mikkola's lab at UCLA studies how different forms of a protein called MLLT3 influence the growth and behavior of human hematopoietic stem cells (HSCs), which are crucial for blood formation. They aim to understand how these protein variants can help improve the self-renewal and differentiation of HSCs, which is important for potential therapies for blood diseases. This research could lead to better ways to generate stem cells for treatments.
hematopoietic stem cellsMLLT3stem cell researchcell differentiationstem cell self-renewal
Research Aims
3AIM 01Investigate the expression levels of MLLT3 isoforms in human HSCs during development.
AIM 02Determine the functional effects of MLLT3 long and short isoforms on HSC maturation.
AIM 03Examine how MLLT3 isoform variants interact with specific protein partners to influence stem cell fate decisions.
Skills the Lab Values
RNA sequencingcell cultureflow cytometryChIP-seqImmunophenotypingmolecular biology techniquesgene expression analysisdata analysis with R/Pythonalternative splicing analysis
Output against the department
Publications48bottom 7% of dept.374th of 402
this lab
most publishedleast published
Citations2.1kbottom 8% of dept.371st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.