Washington University in St Louis · GeneticsNeurogenetics Insight Lab
Joseph D Dougherty · Saint Louis, Missouri
Research Focus
Dr. Joseph D Dougherty's lab at Washington University is focused on understanding how genetic mutations contribute to neurodevelopmental and psychiatric disorders like autism and schizophrenia. By using a variety of mouse models, the lab investigates how these mutations affect brain function and behavior through systematic phenotyping and advanced analysis techniques. The goal is to uncover essential insights into these complex diseases to inform better therapies and interventions.
neurodevelopmental disorderspsychiatric disordersmouse modelsgeneticsbehavioral analysisbrain functionmachine learningtranscriptomics
Research Aims
5AIM 01Investigate the impact of genetic mutations on brain function and behavior.
AIM 02Conduct comprehensive phenotyping of mouse models to assess neuropsychiatric disease mechanisms.
AIM 03Utilize advanced machine learning techniques for behavioral analysis.
AIM 04Perform anatomical mapping to understand the structural changes in the brain due to mutations.
AIM 05Coordinate data sharing to enhance collaboration and replication of findings across research consortia.
Skills the Lab Values
behavioral analysismouse modelsmolecular assessmentssingle nucleus transcriptomicshigh-content imagingautomated home-cage monitoringdata managementgenomic analysis
Output against the department
Publications286top 29% of dept.75th of 259
this lab
most publishedleast published
Citations9.3kbottom 48% of dept.134th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.