The University of Texas Health Science Center at San Antonio · PhysiologyHiroi Lab
Noboru Hiroi · San Antonio, Texas
Research Focus
Dr. Noboru Hiroi's lab focuses on understanding how genetic variations impact cognitive development, particularly through the lens of neurodevelopmental disorders. By using mouse models, the team investigates postnatal cellular mechanisms, specifically looking at how gene variants like Tbx1 contribute to cognitive deficits. This research aims to reveal insights that could lead to new therapeutic strategies for improving cognitive functions in affected individuals.
cognitive developmentneurodevelopmental disordersTbx122q11.2postnatal mechanismscognitive deficitsmyelinationmouse modelsneural stem cells
Research Aims
3AIM 01Evaluate the impacts on cognitive speed of Tbx1 deletion from neural stem/progenitor cells in mice.
AIM 02Identify regions of altered white matter integrity and assess myelination using advanced imaging techniques.
AIM 03Establish the functional roles of TBX1 target genes in cognitive functions in mutant mice.
Skills the Lab Values
mouse modelsbehavioral testing in rodentsdiffusion tensor imaging (DTI)electrophysiologyelectron microscopygene editing techniquescell cultureWestern blotPCR
Output against the department
Publications102bottom 30% of dept.200th of 286
this lab
most publishedleast published
Citations6.3kbottom 49% of dept.146th of 286
this lab
most citedleast cited
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