Stanford University · BiologyMischel Lab
Paul S Mischel · Stanford, California
Research Focus
Dr. Paul S. Mischel's lab at Stanford University focuses on developing new treatments for glioblastoma, a highly aggressive brain cancer. The research aims to discover the proteins that glioblastoma cells depend on for survival, particularly when they have a mutated form of the epidermal growth factor receptor (EGFR). By using advanced chemical and proteomic techniques, the lab seeks to identify drug targets that can lead to more effective therapies for this challenging disease.
glioblastomaEGFRchemical proteomicsdrug discoveryintra-tumoral heterogeneitytarget identificationmetabolic dependenciespatient-derived models
Research Aims
4AIM 01Identify proteins that glioblastoma cells depend on for survival when EGFR is amplified.
AIM 02Discover novel druggable targets specific to EGFR-amplified glioblastomas.
AIM 03Characterize the biochemical pathways involved in tumor growth and resistance.
AIM 04Develop small-molecule libraries to find brain-penetrant ligands that inhibit glioblastoma progression.
Skills the Lab Values
chemical proteomicsactivity-based protein profiling (ABPP)cell culturedrug screeningmolecular biology techniquespatient-derived tumor modelsbiochemical assaysdata analysis using Python
Output against the department
Publications615top 4% of dept.44th of 1,033
this lab
most publishedleast published
Citations41ktop 7% of dept.72nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.