AECAlbert Einstein College of Medicine · Biochemistry
The Apoptosis Initiative
Vern L. Schramm · Bronx, New York
Research Focus
Dr. Vern L. Schramm's lab focuses on developing targeted therapies for cancer based on understanding the mechanisms of enzymes involved in cell death. By studying specific enzymes, such as SAMHD1 and PNP, the lab aims to create effective drug combinations that can improve treatment outcomes for T-cell cancers. The research combines principles of chemistry and biology to design inhibitors that may help patients with resistant cancers.
cancer therapyenzyme inhibitorsSAMHD1PNPT-cell leukemiatransition statedrug developmentapoptosisbiochemical analysis
Research Aims
5AIM 01Investigate the role of SAMHD1 in cancer cell viability.
AIM 02Design inhibitors targeting the transition state of SAMHD1.
AIM 03Evaluate the effectiveness of PNP and SAMHD1 inhibitors in combined therapies.
AIM 04Characterize the interaction between enzyme inhibitors and their targets.
AIM 05Analyze genomic data to understand therapeutic responses in T-cell cancers.
Skills the Lab Values
enzyme kineticskinetic isotope effectscomputational chemistrychemical library screeningprotein dynamicscell culturedrug designanimal modelsbioinformatics
Output against the department
Publications424top 11% of dept.46th of 402
this lab
most publishedleast published
Citations17ktop 26% of dept.104th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.