UMCUniversity of Massachusetts Chan Medical School · Biomedical Engineering
Padron Lab
Raul Padron · Worcester, Massachusetts
Research Focus
Dr. Raul Padron's research lab focuses on understanding how muscles contract and relax, particularly through studying protein structures in skeletal and cardiac muscles. The lab employs advanced imaging techniques to explore the molecular mechanisms behind muscle relaxation, which is crucial for energy conservation. By investigating specific interactions within muscle proteins, Dr. Padron aims to reveal insights relevant to muscle diseases and the effects of therapeutic drugs.
muscle contractionmuscle relaxationmyosinstructural biologycryogenic electron microscopycardiac muscleskeletal muscleenergy metabolismtherapeutic drugscardiomyopathies
Research Aims
3AIM 01Define the structural basis of super-relaxed state in skeletal thick filaments.
AIM 02Investigate conformational changes in myosin heads during relaxation.
AIM 03Analyze the impact of therapeutic drugs on muscle protein structures.
Skills the Lab Values
cryogenic electron microscopysingle particle electron microscopyX-ray diffractionprotein purificationbiochemical assaysmolecular modelingcell culture techniquesmuscle histologydata analysis in structural biology
Output against the department
Publications111bottom 21% of dept.468th of 595
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.447th of 595
this lab
most citedleast cited
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