University of California-San Francisco · PharmacologyGiacomini Transporters Lab
Kathleen M Giacomini · San Francisco, California
Research Focus
Dr. Kathleen Giacomini's lab at UCSF focuses on studying membrane transporters, which are crucial for moving drugs, nutrients, and other substances across cell membranes, especially in the brain. The lab seeks to understand how these transporters work in the blood-brain barrier, a critical site that regulates what enters the brain. By using cutting-edge methods like structural biology and computational modeling, the team aims to identify potential new treatments and improve our understanding of drug delivery in the brain.
membrane transportersblood-brain barriersolute carrierATP-binding cassettestructural biologydrug deliveryneuroactive compoundscomputational biologyligand specificity
Research Aims
3AIM 01Characterize the ligand specificity of under-studied transporters at the blood-brain barrier.
AIM 02Determine the structure of key transporters using cryo-electron microscopy.
AIM 03Investigate the localization and function of transporters in human endothelial cell models.
Skills the Lab Values
in silico dockingcryogenic electron microscopycell line generationfunctional assayslocalization studiesproteomicsimmunohistochemistrydata analysis with Pythonchemo-informatics
Output against the department
Publications437top 13% of dept.60th of 462
this lab
most publishedleast published
Citations26ktop 12% of dept.54th of 462
this lab
most citedleast cited
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