University of California-San Francisco · BiologyChromosome Segregation Lab
Sophie Dumont · San Francisco, California
Research Focus
Dr. Sophie Dumont's lab at UCSF studies how chromosomes are accurately segregated during cell division, a crucial process for cell health. They explore the physical and molecular mechanisms behind this process, particularly focusing on the spindle and kinetochore structures that help move chromosomes. Through innovative techniques like microneedle manipulation and live cell imaging, the lab aims to understand the fundamental principles of chromosome segregation, which has important implications for understanding cancer and congenital abnormalities.
chromosome segregationspindle dynamicskinetochore mechanicscell divisionlive cell imaging
Research Aims
5AIM 01Investigate how the spindle architecture is maintained during division.
AIM 02Examine the roles of mechanical forces in chromosome segregation.
AIM 03Explore the interactions between kinetochore proteins and microtubules.
AIM 04Determine how chromosome size influences segregation mechanics.
AIM 05Understand the implications of segregation errors for health and disease.
Skills the Lab Values
microneedle manipulationlive cell imagingmolecular biology techniquesmechanics of cellular structuresdata modeling
Output against the department
Publications117bottom 42% of dept.603rd of 1,033
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.691st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.