University of South Florida · PhysiologyHeparan Sulfate and Alzheimer's Research Group
Lianchun Wang · Tampa, Florida
Research Focus
Dr. Lianchun Wang's research lab at the University of South Florida focuses on understanding the role of heparan sulfate proteoglycans in Alzheimer's disease. They investigate how these molecules affect the clearance of amyloid beta from the brain, which is crucial in preventing the progression of this disease. By studying both human samples and mouse models, the lab aims to uncover new mechanisms that could potentially lead to effective therapies for Alzheimer's.
Alzheimer's DiseaseAmyloid ClearanceHeparan SulfateNeurovascular HealthBrain Proteins
Research Aims
3AIM 01Investigate the role of brain endothelial cell heparan sulfate in amyloid beta clearance.
AIM 02Explore the mechanisms of brain endothelial cell heparan sulfate in Alzheimer's disease pathogenesis.
AIM 03Assess the function of vascular smooth muscle cell heparan sulfate in clearing amyloid beta.
Skills the Lab Values
cell culturegenetic studiesmouse modelsbiochemical assaysRNA sequencingscRNA-seqmolecular biologydata analysisspecimen handling
Output against the department
Publications159top 45% of dept.130th of 286
this lab
most publishedleast published
Citations7.4ktop 45% of dept.129th of 286
this lab
most citedleast cited
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