Case Western Reserve University · NeuroscienceDeneris Lab
Evan S Deneris · Cleveland, Ohio
Research Focus
Dr. Evan Deneris's lab at Case Western Reserve University focuses on understanding how different types of serotonin neurons develop in the brain. They use advanced techniques to examine how genes and regulatory mechanisms shape these neurons and how disruptions in these processes could lead to neurodevelopmental disorders, like autism and depression. The lab combines expertise in molecular biology, genomics, and neuroscience to unravel these complex questions.
serotonin neuronsgene regulatory mechanismsneurodevelopmentsingle cell RNA-seqchromatin accessibilitytranscription factorsneuropsychiatric diseases5-HT neuron subtypesbioinformatics
Research Aims
3AIM 01Define the developmental trajectories of serotonin neuron subtypes.
AIM 02Investigate the control of serotonin neuron subtype transcriptomes by Pet1 and Lmx1b.
AIM 03Determine the chromatin mechanisms involved in the generation of serotonin neuron subtypes.
Skills the Lab Values
single cell RNA sequencingflow cytometrychromatin accessibility assaysmouse model techniquestransgenic organismsbioinformatics analysiscell sortinggenome sequencingelectrophysiology
Output against the department
Publications108bottom 37% of dept.421st of 671
this lab
most publishedleast published
Citations12ktop 33% of dept.220th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.