University of California-San Diego · PharmacologyPKA Signaling and Neurodegeneration Lab
Susan S. Taylor · La Jolla, California
Research Focus
Dr. Susan S. Taylor's lab at UC San Diego focuses on understanding how protein kinase A (PKA) signaling works at a molecular level and how it is linked to various diseases, particularly neurodegenerative conditions. The lab utilizes a multidisciplinary approach that combines biochemistry, biophysics, and molecular biology to explore how different PKA isoforms function and localize within neurons. Through advanced imaging techniques and structural biology, they aim to uncover the underlying mechanisms of PKA regulation and its implications in health and disease.
PKAneurodegenerative diseasesprotein kinaseneuron signalingbiomolecular condensates
Research Aims
5AIM 01Characterize the structure and function of PKA holoenzymes
AIM 02Investigate the role of specific PKA isoforms in neurons
AIM 03Understand the impact of PKA mutations on disease pathology
AIM 04Explore the dynamics of PKA signaling in cellular environments
AIM 05Identify the effects of phase separation on PKA function
Skills the Lab Values
Molecular cloningProtein expression and purificationX-ray crystallographyCryo-Electron Microscopy (cryoEM)Fluorescence microscopy
Output against the department
Publications710top 5% of dept.21st of 462
this lab
most publishedleast published
Citations48ktop 5% of dept.22nd of 462
this lab
most citedleast cited
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