University of Virginia-Main Campus · ChemistryAntibiotic Resistance Research Lab
Marcos M. Pires · Charlottesville, Virginia
Research Focus
Dr. Marcos M. Pires' lab at the University of Virginia focuses on understanding how bacteria like Mycobacterium tuberculosis and Acinetobacter baumannii resist antibiotics. By investigating the structural properties of bacterial membranes, the lab aims to uncover ways to enhance the effectiveness of existing antibiotics and develop new ones. They utilize advanced screening methods to analyze how drugs interact with bacterial cells, which is critical for improving treatment options for drug-resistant infections.
antibiotic resistancebacterial membranessmall molecule screeningMycobacterium tuberculosisAcinetobacter baumannii
Research Aims
5AIM 01Investigate the molecular determinants of antibiotic permeability in Mycobacterium tuberculosis.
AIM 02Develop high-throughput methods to assess drug accumulation in Acinetobacter baumannii.
AIM 03Identify chemical properties that facilitate drug penetration in bacterial membranes.
AIM 04Discover new compounds that can disrupt bacterial membranes to enhance antibiotic effectiveness.
AIM 05Explore the relationship between bacterial membrane composition and drug resistance.
Skills the Lab Values
high-throughput screeningmolecular biology techniquesbacterial geneticschemical analysisdata analysis with machine learning
Output against the department
Publications131bottom 30% of dept.151st of 216
this lab
most publishedleast published
Citations2.2kbottom 17% of dept.180th of 216
this lab
most citedleast cited
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