Massachusetts Institute of Technology · EngineeringCaspiTal Immunology Lab
Michal Caspi Tal · Cambridge, Massachusetts
Research Focus
The research lab led by Michal Caspi Tal at MIT focuses on understanding Lyme disease, specifically how to predict patient recovery and persistent symptoms following treatment. They are investigating immune biomarkers that can inform on the body's response to the bacteria Borrelia burgdorferi. Through innovative techniques, including a new technology called FLIP, the team aims to profile various immune responses and ultimately improve clinical outcomes for Lyme disease patients.
Lyme diseaseimmune biomarkersantibody profilingBorrelia burgdorferipatient recoverypersistent symptomsimmune response
Research Aims
5AIM 01Identify immune biomarkers that predict recovery from Lyme disease
AIM 02Develop the FLIP technology to profile immune responses in Lyme disease patients
AIM 03Investigate the role of different antibody isotypes in persistent Lyme disease symptoms
AIM 04Test the predictive capability of the identified biomarker in prospective patient cohorts
AIM 05Enhance understanding of immune mechanisms contributing to Lyme disease symptoms.
Skills the Lab Values
Flow cytometryantibody isotypingplasma samplinganimal modelsimmunological assaysdata analysisbioinformaticsclinical trial designbiomarker validation
Output against the department
Publications53bottom 7% of dept.258th of 278
this lab
most publishedleast published
Citations4.0kbottom 29% of dept.196th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.